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The War Against Cancer-
Can Beta Glucan Serve a Role?
An article by A. J. Lanigan
CEO, Transfer Point
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For many decades, immune therapy has been investigated, utilized, and found to
have frequent success in helping the body's immune system fight disease. One of the most
feared diseases, cancer, continues to take its toll. Until a cure is found, we may have some
answers to slow the progression or help the recovery of cancer patients. One area of immune
enhancement concentrates on complex carbohydrates, specifically beta glucan.
In the United States, and in various other parts of the world, the Beta 1, 3-D polyglucose (a
complex carbohydrate) molecules have come under intense scrutiny. The Japanese have extracted a
pharmaceutical material from a fungal form and called it Krestin (PSK). This is a protein bound
carbohydrate molecule that has exhibited antitumor effects in many test tube, animal, and human
studies. It exhibits many of the classical characteristics of its U.S. relative, Beta Glucan (BG)
from baker’s yeast. Beta Glucan has almost 40 years of peer reviewed research attesting to its
safety and efficacy. Baker’s yeast (also a fungal form) carries a GRAS (Generally Regarded As Safe)
rating from the FDA, having no known toxicity. Although the mushroom fungal material cannot make
that claim, animal experiments have shown little toxicity at 20,000 mg/kg of body weight. That
would be over 1600 grams (3.5 lbs.) for a 150 lb. human. (drink plenty of water with that
dose).
In further comparison, the PSK contains about 75% of the glucose linkage backbone versus 95% in BG.
The side chains of these polybranched sugar molecules vary as well. With PSK, mannose, xylose,
galactose, and fucose sugars side branch to the 1,3 linkage central sugar molecule. Many U.S.
scientists have determined that these side chain variations and frequencies hold the "key into a
lock" mechanism that causes certain immune cells to fight the fight and communicate better to
defeat cancer and other diseases. Perfecting processes that purify without destroying these natural
molecules are imperative in giving researchers and clinicians the material they need to properly
dose and deliver consistent results. We see the 1,3 glucose at around 85% with 3-5% 1,6 glucose
side chains in BG.
Although many aspects of exactly how these complex molecules work in the immune system are not
clearly understood, four decades of experimentation and use dictate that something is there
meriting the use of the material. Scientists and clinicians largely agree that these complex
carbohydrates will help return suppressed or enhanced immune responses back to normal levels. In
the Killer T cell population (an important antitumor immune cell), activity levels correlate well
with the use of these complex carbohydrates. Natural Killer cells and complement show significant
effectiveness, according to considerable research by several institutions in the US. Other immune
suppressing substances seem to be negated and the intestinal immune system, in particular, appears
to be modulated by the oral doses. Finally, it is noted that both the large and the small molecules
pass through the intestine and can be traced to the blood using appropriate tracking techniques
when taken orally.
We are happy to announce a continuation of human clinical trials using our Beta Glucan along side
the conventional medical treatments. We expect to clearly show the efficacy of our material, when
appropriate steps are taken to purify the BG, while leaving the active molecules intact. With a
standardized material such as ours, researchers and clinicians can always depend upon the correct
dosage. This will help to provide the best immune response and positive outcomes for their
patients.
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Potency Of This Product
This chart reflects the results of a major US university
testing on a side-by-side competitive basis, the ability of Transfer Point's
Beta 1, 3-D Glucan, manufactured by Transfer Point ( A. J. Lanigan AKA: AJs)
to increase the number of immune cells (expressed here in a percentage) that
are attacking and destroying non-self targets. All these cells have CR3 (1,
3/1, 6 glucan) receptors.
This is an ongoing study that will help to eliminate any
confusion in the market place relative to which compounds and what brands of
product perform the best.
Transfer Point offers customers a comprehensive assay
detailing both purity and potency. No one in the industry has ever matched
their purity and potency, regardless of claims. Many competitors are
unwilling to provide you with such information, calling it proprietary. As a
consumer, paying for a product based upon specific claims of purity and
potency, you are entitled to know what you have bought.
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Two companies were tested at up to 160 times the dose
of Transfer Point stand alone Beta 1, 3-D Glucan. They are shown at
or near the negative control (30.6%).
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Numerous assays have confirmed to date that “loading”
or putting 2-3 times the amount of powder into a single dose does
next to nothing. If fact, Transfer Point tested up to 64:1 and that
level failed in every instance to double the biological effective of
the compounds tested.
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Transfer Point tested for the production of 14
cytokines (immune system messenger molecules), including the
inflammatory cytokines. Their compounds showed zero (0) to nearly
non-detectable levels. Some immune supplements may actually be
deleterious when used too often or if the individual already has
issue with disease that does not fair well with excessive
inflammation.
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Transfer Point compounds produce significant levels of
IL-2*. This is a key cytokine that results in many positive effects
on the overall immune system and its ability to respond, especially
to cancer and viruses.
*IL-2 - Interleukin-2 was discovered more than 20 years ago.
IL-2 is part of a family of proteins called cytokines. Cytokines act
primarily by communicating between the various cells of the body's immune
system. IL-2 helps increase production of several different components of the
immune system found in the blood, including T lymphocytes and natural killer
cells. It also may improve the function of other immune system cells, such as
lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes.
This helps the body fight cancer.
IL-2, produced and secreted by activated Th1-cells, is the
major interleukin responsible for clonal T-cell proliferation. The production
of IL-2 occurs primarily by CD4+ T-helper cells. The IL-2 receptor is not
expressed on the surface of resting T-cells and is present only transiently
on the surface of T-cells, disappearing within 6-10 days of antigen
presentation. In contrast to T-helper cells, NK cells constitutively express
IL-2 receptors and will secrete TNF-a, IFN-g and GM-CSF in response to IL-2,
which in turn activate macrophages. The U.S. Food and Drug Administration
approved a synthetic form of IL-2 (Proleukin) for treatment against cancer in
1992.
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